Crystal structure of the bacterial YhcH protein indicates a role in sialic acid catabolism.
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ABSTRACT:
SUBMITTER: Teplyakov A
PROVIDER: S-EPMC1196062 | biostudies-literature | 2005 Aug
REPOSITORIES: biostudies-literature
Publications
Crystal structure of the bacterial YhcH protein indicates a role in sialic acid catabolism.
Teplyakov Alexey A Obmolova Galina G Toedt John J Galperin Michael Y MY Gilliland Gary L GL
Journal of bacteriology 20050801 16
The yhcH gene is part of the nan operon in bacteria that encodes proteins involved in sialic acid catabolism. Determination of the crystal structure of YhcH from Haemophilus influenzae was undertaken as part of a structural genomics effort in order to assist with the functional assignment of the protein. The structure was determined at 2.2-A resolution by multiple-wavelength anomalous diffraction. The protein fold is a variation of the double-stranded beta-helix. Two antiparallel beta-sheets for ...[more]
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