Ontology highlight
ABSTRACT:
SUBMITTER: Levine OB
PROVIDER: S-EPMC8382748 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Levine Olivia B OB Skelly Mary Jane MJ Miller John D JD Rivera-Irizarry Jean K JK Rowson Sydney A SA DiBerto Jeffrey F JF Rinker Jennifer A JA Thiele Todd E TE Kash Thomas L TL Pleil Kristen E KE
Nature communications 20210823 1
Bed nucleus of the stria terminalis (BNST) neurons that synthesize corticotropin-releasing factor (CRF) drive binge alcohol drinking and anxiety. Here, we found that female C57BL/6J mice binge drink more than males and have greater basal BNST<sup>CRF</sup> neuron excitability and synaptic excitation. We identified a dense VGLUT2 + synaptic input from the paraventricular thalamus (PVT) that releases glutamate directly onto BNST<sup>CRF</sup> neurons but also engages a large BNST interneuron popul ...[more]