Mechanism of action of glycyrrhizin against Plasmodium falciparum.
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ABSTRACT:
SUBMITTER: Soeiro MNC
PROVIDER: S-EPMC8384254 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
Mechanism of action of glycyrrhizin against Plasmodium falciparum.
Soeiro Maria de Nazaré Correia MNC Vergoten Gérard G Bailly Christian C
Memorias do Instituto Oswaldo Cruz 20210820
Extracts of the plant Glycyrrhiza glabra (licorice) are used in traditional medicine to treat malaria. The main active components are the saponin glycyrrhizin (GLR) and its active metabolite glycyrrhetinic acid (GA) which both display activities against Plasmodium falciparum. We have identified three main mechanisms at the origin of their anti-plasmodial activity: (i) drug-induced disorganisation of membrane lipid rafts, (ii) blockade of the alarmin protein HMGB1 and (iii) potential inhibition o ...[more]
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2024-06-08 | GSE234872 | GEO