Ontology highlight
ABSTRACT:
SUBMITTER: Kotani T
PROVIDER: S-EPMC8389409 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Kotani Takenori T Ihara Noriko N Okamoto Saki S Setiawan Jajar J Konno Tasuku T Saito Yasuyuki Y Murata Yoji Y Matozaki Takashi T
PloS one 20210826 8
Cross talk between different signaling pathways is thought to be important for regulation of homeostasis of, as well as oncogenesis of, the intestinal epithelium. Expression of an active form of K-Ras specifically in intestinal epithelial cells (IECs) of mice (IEC-RasDA mice) resulted in the development of hyperplasia in the small intestine and colon of mice. IEC-RasDA mice also manifested the increased proliferation of IECs. In addition, the number of goblet cells markedly increased, while that ...[more]