Personalized health and the coronavirus vaccines-Do individual genetics matter?

ABSTRACT: Vaccines represent preventative interventions amenable to immunogenetic prediction of how human variability will influence their safety and efficacy. The genetic polymorphism among individuals within any population can render possible that the immunity elicited by a vaccine is variable in length and strength. The same immune challenge (virus and/or vaccine) could provoke partial, complete or even failed protection for some individuals treated under the same conditions. We review genetic variants and mechanistic relationships among chemokines, chemokine receptors, interleukins, interferons, interferon receptors, toll-like receptors, histocompatibility antigens, various immunoglobulins and major histocompatibility complex antigens. These are the targets for variation among macrophages, dendr

SUBMITTER: Valdes-Fernandez BN 

PROVIDER: S-EPMC8390434 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature