Proteomics

Dataset Information

0

Iimmunopeptidomics pipeline for generation of personalized oncolytic cancer vaccines.

ABSTRACT: We used a streamlined pipeline for the generation of personalized cancer vaccines starting from the isolation and selection of the most immunogenic peptide candidates expressed on the tumour cells and ending in the generation of efficient therapeutic oncolytic cancer vaccines. We used MHC-I immunoaffinity purification in a murine colon tumor model from CT26 cells. The selection of the target candidates was then based on two separate approaches: RNAseq analysis and HEX software.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Colon

DISEASE(S): Colon Cancer

SUBMITTER: Rui Branca  

LAB HEAD: Janne Lehtiö

PROVIDER: PXD026463 | Pride | 2022-04-06

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
Sara_Ligandome_20200421_murine-CT26-120320-RQ1.zip Other
Sara_Ligandome_20200421_murine-CT26-120320-RQ2.zip Other
Sara_Ligandome_20200421_murine-CT26-190220-R1-Jaco.zip Other
Sara_Ligandome_20200421_murine-CT26-190220-R2-Sara.zip Other
Sara_Ligandome_murine_CT26_120320_RQ1_10of10ul_Slot2-19_20-04-18_1167.d.zip Other
Items per page:
1 - 5 of 9
altmetric image

Publications

Besides the isolation and identification of major histocompatibility complex I-restricted peptides from the surface of cancer cells, one of the challenges is eliciting an effective antitumor CD8+ T-cell-mediated response as part of therapeutic cancer vaccine. Therefore, the establishment of a solid pipeline for the downstream selection of clinically relevant peptides and the subsequent creation of therapeutic cancer vaccines are of utmost importance. Indeed, the use of peptides for eliciting spe  ...[more]

Similar Datasets

Proteomics Exploiting trogocytosis by Immunopeptidomics to profile tumor associated antigens (TAA) actively targeted by tumor specific T cells in leukemia.
2023-09-07 | PXD035344 | Pride
Proteomics Immunopeptidomics of malignant mesothelioma to identify target antigens for T cell Immunotherapy
2023-09-08 | PXD038273 | Pride
Proteomics Immunopeptidome of Human Renal Cell Carcinoma (RCC) derived cells infected with oncolytic viruses.
2025-05-06 | PXD051880 | Pride
Proteomics Immunopeptidomics by use of a microfluidics chip.
2022-02-17 | PXD022194 | Pride
Proteomics Molecular Structure and Enzymatic Mechanism of the Human Collagen Hydroxylysine Galactosyltransferase GLT25D1/COLGALT1
2025-03-05 | PXD061021 | Pride
Proteomics The endocannabinoid 2-arachidonoylglycerol is released and transported on demand via extracellular microvesicles
2025-02-27 | PXD056498 | Pride
Proteomics Ubiquitin-specific proximity labeling for the identification of E3 ubiquitin ligase substrates
2024-03-20 | PXD042698 | Pride
Proteomics Ubiquitin-specific proximity labeling for the identification of E3 ubiquitin ligase substrates
2024-03-20 | PXD042700 | Pride
Proteomics Ubiquitin-specific proximity labeling for the identification of E3 ubiquitin ligase substrates
2024-03-20 | PXD042702 | Pride
Proteomics Mutations in epitope flanking regions for SARS-CoV-2 nucleoprotein affect proteasomal processing to alter CD8+ T cell responses
2023-10-24 | PXD032054 | Pride