Proteomics

Dataset Information

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Iimmunopeptidomics pipeline for generation of personalized oncolytic cancer vaccines.

ABSTRACT: We used a streamlined pipeline for the generation of personalized cancer vaccines starting from the isolation and selection of the most immunogenic peptide candidates expressed on the tumour cells and ending in the generation of efficient therapeutic oncolytic cancer vaccines. We used MHC-I immunoaffinity purification in a murine colon tumor model from CT26 cells. The selection of the target candidates was then based on two separate approaches: RNAseq analysis and HEX software.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Colon

DISEASE(S): Colon Cancer

SUBMITTER: Rui Branca  

LAB HEAD: Janne Lehtiö

PROVIDER: PXD026463 | Pride | 2022-04-06

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
Sara_Ligandome_20200421_murine-CT26-120320-RQ1.zip Other
Sara_Ligandome_20200421_murine-CT26-120320-RQ2.zip Other
Sara_Ligandome_20200421_murine-CT26-190220-R1-Jaco.zip Other
Sara_Ligandome_20200421_murine-CT26-190220-R2-Sara.zip Other
Sara_Ligandome_murine_CT26_120320_RQ1_10of10ul_Slot2-19_20-04-18_1167.d.zip Other
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Publications

Besides the isolation and identification of major histocompatibility complex I-restricted peptides from the surface of cancer cells, one of the challenges is eliciting an effective antitumor CD8+ T-cell-mediated response as part of therapeutic cancer vaccine. Therefore, the establishment of a solid pipeline for the downstream selection of clinically relevant peptides and the subsequent creation of therapeutic cancer vaccines are of utmost importance. Indeed, the use of peptides for eliciting spe  ...[more]

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