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Systemic Investigation Identifying Salivary miR-196b as a Promising Biomarker for Early Detection of Head-Neck Cancer and Oral Precancer Lesions.


ABSTRACT: Liquid biopsy is a rapidly growing field, for it may provide a minimally invasive way to acquire pathological data for personalized medicine. This study developed a systemic strategy to discover an effective salivary biomarker for early detection of patients with head-neck squamous carcinoma (HNSC) and oral precancer lesion (OPC). A total of 10 miRNAs were examined in parallel with multiple independent cohorts. These included a training set of salivary samples from HNSC patients, the TCGA-HNSC and GSE31277 cohorts to differentiate miRNAs between tumor and normal tissues, and groups of salivary samples from healthy individuals, patients with HNSC and OPC. The combined results from the salivary training set and the TCGA-HNSC cohort showed that four miRNAs (miR-148b, miR-155, miR-196b, and miR-31) consistently increased in HNSC patients. Further integration with the GSE31277 cohort, two miRNAs (miR-31 and miR-196b) maintained at high significances. Further assessment showed that salivary miR-196b was a prominent diagnostic biomarker, as it remarkably discriminated between healthy individuals and patients with HNSC (p < 0.0001, AUC = 0.767, OR = 5.64) or OPC (p < 0.0001, AUC = 0.979, OR = 459). Salivary miR-196b could be an excellent biomarker for diagnosing OPC and early detection of HNSC. This molecule may be used for early screening high-risk groups of HNSC.

SUBMITTER: Cheng AJ 

PROVIDER: S-EPMC8392418 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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Systemic Investigation Identifying Salivary miR-196b as a Promising Biomarker for Early Detection of Head-Neck Cancer and Oral Precancer Lesions.

Cheng Ann-Joy AJ   You Guo-Rung GR   Lee Che-Jui CJ   Lu Ya-Ching YC   Tang Shang-Ju SJ   Huang Yi-Fang YF   Huang Yu-Chen YC   Lee Li-Yu LY   Fan Kang-Hsing KH   Chen Yen-Chao YC   Huang Shiang-Fu SF   Chang Joseph Tung-Chieh JT  

Diagnostics (Basel, Switzerland) 20210804 8


<h4>Background</h4>Liquid biopsy is a rapidly growing field, for it may provide a minimally invasive way to acquire pathological data for personalized medicine. This study developed a systemic strategy to discover an effective salivary biomarker for early detection of patients with head-neck squamous carcinoma (HNSC) and oral precancer lesion (OPC).<h4>Methods</h4>A total of 10 miRNAs were examined in parallel with multiple independent cohorts. These included a training set of salivary samples f  ...[more]

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