Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC8392728 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Wang Jingkai J Lin Kaicheng K Hu Huijie H Qie Xingwang X Huang Wei E WE Cui Zhisong Z Gong Yan Y Song Yizhi Y
Biosensors 20210820 8
Traditional in vitro anticancer drug sensitivity testing at the population level suffers from lengthy procedures and high false positive rates. To overcome these defects, we built a confocal Raman microscopy sensing system and proposed a single-cell approach via Raman-deuterium isotope probing (Raman-DIP) as a rapid and reliable in vitro drug efficacy evaluation method. Raman-DIP detected the incorporation of deuterium into the cell, which correlated with the metabolic activity of the cell. The ...[more]