Genetic Suppressor Element 1 (GSE1) Promotes the Oncogenic and Recurrent Phenotypes of Castration-Resistant Prostate Cancer by Targeting Tumor-Associated Calcium Signal Transducer 2 (TACSTD2).

ABSTRACT:

Background

prostate cancer (PCa) is a principal cause of cancer-related morbidity and mortality. Castration resistance and metastasis are clinical challenges and continue to impede therapeutic success, despite diagnostic and therapeutic advances. There are reports of the oncogenic activity of genetic suppressor element (GSE)1 in breast and gastric cancers; however, its role in therapy resistance, metastasis, and susceptibility to disease recurrence in PCa patients remains unclear.

Objective

this study investigated the role of aberrantly expressed GSE1 in the metastasis, therapy resistance, relapse, and poor prognosis of advanced PCa.

Methods

we used a large cohort of multi-omics data and in vitro, ex vivo, and in vivo assays to investigate the potential effect of alte

SUBMITTER: Bamodu OA 

PROVIDER: S-EPMC8392851 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature