Ontology highlight
ABSTRACT:
SUBMITTER: Dufait I
PROVIDER: S-EPMC5173167 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Dufait Inès I Van Valckenborgh Els E Menu Eline E Escors David D De Ridder Mark M Breckpot Karine K
Oncotarget 20160701 27
Cancer progression is in part determined by interactions between cancer cells and stromal cells in the tumor microenvironment (TME). The identification of cytotoxic tumor-infiltrating lymphocytes has instigated research into immune stimulating cancer therapies. Although a promising direction, immunosuppressive mechanisms exerted at the TME hamper its success. Myeloid-derived suppressor cells (MDSCs) have come to the forefront as stromal cells that orchestrate the immunosuppressive TME. Consequen ...[more]