Neutrophil in the Pancreatic Tumor Microenvironment.
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ABSTRACT:
SUBMITTER: Jin L
PROVIDER: S-EPMC8394314 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Publications
Neutrophil in the Pancreatic Tumor Microenvironment.
Jin Lin L Kim Hong Sun HS Shi Jiaqi J
Biomolecules 20210807 8
Pancreatic ductal adenocarcinoma (PDAC) is a malignancy with a poor prognosis and low survival rates. PDAC is characterized by a fibroinflammatory tumor microenvironment enriched by abundant fibroblasts and a variety of immune cells, contributing to its aggressiveness. Neutrophils are essential infiltrating immune cells in the PDAC microenvironment. Recent studies have identified several cellular mechanisms by which neutrophils are recruited to tumor lesion and promote tumorigenesis. This review ...[more]
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