Unknown

Dataset Information

0

Cytoskeleton and Associated Proteins: Pleiotropic JNK Substrates and Regulators.


ABSTRACT: This review extensively reports data from the literature concerning the complex relationships between the stress-induced c-Jun N-terminal kinases (JNKs) and the four main cytoskeleton elements, which are actin filaments, microtubules, intermediate filaments, and septins. To a lesser extent, we also focused on the two membrane-associated cytoskeletons spectrin and ESCRT-III. We gather the mechanisms controlling cytoskeleton-associated JNK activation and the known cytoskeleton-related substrates directly phosphorylated by JNK. We also point out specific locations of the JNK upstream regulators at cytoskeletal components. We finally compile available techniques and tools that could allow a better characterization of the interplay between the different types of cytoskeleton filaments upon JNK-mediated stress and during development. This overview may bring new important information for applied medical research.

SUBMITTER: Benoit B 

PROVIDER: S-EPMC8395060 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC9698833 | biostudies-literature
| S-EPMC8880164 | biostudies-literature
| S-EPMC99619 | biostudies-literature
| S-EPMC1218852 | biostudies-other
| S-EPMC10047310 | biostudies-literature
| S-EPMC4305408 | biostudies-literature
| S-EPMC8405906 | biostudies-literature
| S-EPMC4067751 | biostudies-literature
| S-EPMC2289750 | biostudies-other
| S-EPMC4177944 | biostudies-literature