Browse
Submit Data
Databases
API
Help

Dataset Information

24 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Quantitative Assessment of Point-of-Care 3D-Printed Patient-Specific Polyetheretherketone (PEEK) Cranial Implants.

ABSTRACT: Recent advancements in medical imaging, virtual surgical planning (VSP), and three-dimensional (3D) printing have potentially changed how today's craniomaxillofacial surgeons use patient information for customized treatments. Over the years, polyetheretherketone (PEEK) has emerged as the biomaterial of choice to reconstruct craniofacial defects. With advancements in additive manufacturing (AM) systems, prospects for the point-of-care (POC) 3D printing of PEEK patient-specific implants (PSIs) have emerged. Consequently, investigating the clinical reliability of POC-manufactured PEEK implants has become a necessary endeavor. Therefore, this paper aims to provide a quantitative assessment of POC-manufactured, 3D-printed PEEK PSIs for cranial reconstruction through characterization of the geometrical, morphological, and biomechanical aspects of the in-hospital 3D-printed PEEK cranial implants. The study results revealed that the printed customized cranial implants had high dimensional accuracy and repeatability, displaying clinically acceptable morphologic similarity concerning fit and contours continuity. From a biomechanical standpoint, it was noticed that the tested implants had variable peak load values with discrete fracture patterns and failed at a mean (SD) peak load of 798.38 ± 211.45 N. In conclusion, the results of this preclinical study are in line with cranial implant expectations; however, specific attributes have scope for further improvements.

SUBMITTER: Sharma N

PROVIDER: S-EPMC8395180 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Similar Datasets

Accuracy Assessment of Molded, Patient-Specific Polymethylmethacrylate Craniofacial Implants Compared to Their 3D Printed Originals.

Project description:The use of patient-specific implants (PSIs) in craniofacial surgery is often limited due to a lack of expertise and/or production costs. Therefore, a simple and cost-efficient template-based fabrication workflow has been developed to overcome these disadvantages. The aim of this study is to assess the accuracy of PSIs made from their original templates. For a representative cranial defect (CRD) and a temporo-orbital defect (TOD), ten PSIs were made from polymethylmethacrylate (PMMA) using computer-aided design (CAD) and three-dimensional (3D) printing technology. These customized implants were measured and compared with their original 3D printed templates. The implants for the CRD revealed a root mean square (RMS) value ranging from 1.128 to 0.469 mm with a median RMS (Q1 to Q3) of 0.574 (0.528 to 0.701) mm. Those for the TOD revealed an RMS value ranging from 1.079 to 0.630 mm with a median RMS (Q1 to Q3) of 0.843 (0.635 to 0.943) mm. This study demonstrates that a highly precise duplication of PSIs can be achieved using this template-molding workflow. Thus, virtually planned implants can be accurately transferred into haptic PSIs. This workflow appears to offer a sophisticated solution for craniofacial reconstruction and continues to prove itself in daily clinical practice.

| S-EPMC7141183 | biostudies-literature

Neutron Shielding Performance of 3D-Printed Boron Carbide PEEK Composites.

Project description:Polyethylene is used as a traditional shielding material in the nuclear industry, but still suffers from low softening point, poor mechanical properties, and difficult machining. In this study, novel boron carbide polyether-ether-ketone (PEEK) composites with different mass ratios were prepared and tested as fast neutron absorbers. Next, shielding test pieces with low porosity were rapidly manufactured through the fused deposition modeling (FDM)-3D printing optimization process. The respective heat resistances, mechanical properties, and neutron shielding characteristics of as-obtained PEEK and boron carbide PEEK composites with different thicknesses were then evaluated. At load of 0.45 MPa, the heat deformation temperature of boron carbide PEEK increased with the boron carbide content. The heat deformation temperature of 30% wt. boron carbide PEEK was recorded as 308.4 °C. After heat treatment, both tensile strength and flexural strength of PEEK and PEEK composites rose by 40%-50% and 65%-78%, respectively. Moreover, the as-prepared composites showed excellent fast neutron shielding performances. For shielding test pieces with thicknesses between 40 mm and 100 mm, the neutron shielding rates exhibited exponential variation as a function of boron carbide content. The addition of 5%-15% boron carbide significantly changed the curvature of the shielding rate curve, suggesting an optimal amount of boron carbide. Meanwhile, the integrated shielding/structure may effectively shield neutron radiation, thereby ensuring optimal shielding performances. In sum, further optimization of the proposed process could achieve lightweight materials with less consumables and small volume.

| S-EPMC7287577 | biostudies-literature

Clinical efficacy of peek patient-specific implants in orbital reconstruction.

Project description:Purpose:To assess the clinical efficacy of custom made PEEK patient-specific implants in treatment of orbital wall defects. Methods:Forty-five patients with unilateral post-traumatic orbital wall defects were enrolled in the study. They underwent subsequent reconstructive procedures using PEEK patient-specific implants (PSI) or pre-bent titanium plates. All the patients were examined with the standardized algorithm, including local status examination, vision assessment and computer tomography (CT) with measurements of the orbital volume. A comparative analysis of the treatment outcomes in two groups of patients (pre-bent plates/PSI) was performed. Results:The study findings show an absence of any postoperative infection, inflamation or decreased visual acuity in either group. In PSI group, diplopia after surgery was absent in 82.1% of patients versus 70.6% of controls. The mean duration of surgery was 54.25 ± 16.8 min with PSI application and 82.9 ± 10.8 min with pre-bent plates. The mean difference between the intact and damaged orbital volume was 1.9 ± 1.4 cm3 in the control group versus 0.74 ± 0.6 cm3 in PSI group (?<0.05). Conclusion:PEEK PSI demonstrated higher clinical efficacy in comparison to pre-bent plates in orbital wall reconstruction especially in restoring the volume and shape of the damaged orbit.

| S-EPMC7029176 | biostudies-literature

Osteointegration of 3D-Printed Fully Porous Polyetheretherketone Scaffolds with Different Pore Sizes.

Project description:Polyetheretherketone (PEEK) constitutes a preferred alternative material for orthopedic implants owing to its good mechanical properties and biocompatibility. However, the poor osseointegration property of PEEK implants has limited their clinical applications. To address this issue, in this study, we investigated the mechanical and biological properties of fully porous PEEK scaffolds with different pore sizes both in vitro and in vivo. PEEK scaffolds with designed pore sizes of 300, 450, and 600 μm and a porosity of 60% were manufactured via fused deposition modeling (FDM) to explore the optimum pore size. Smooth solid PEEK cylinders (PEEK-S) were used as the reference material. The mechanical, cytocompatibility, proliferative, and osteogenic properties of PEEK scaffolds were characterized in comparison to those of PEEK-S. In vivo dynamic contrast-enhanced magnetic resonance imaging, microcomputed tomography, and histological observation were performed after 4 and 12 weeks of implantation to evaluate the microvascular perfusion and bone formation afforded by the various PEEK implants using a New Zealand white rabbit model with distal femoral condyle defects. Results of in vitro testing supported the good biocompatibility of the porous PEEK scaffolds manufactured via FDM. In particular, the PEEK-450 scaffolds were most beneficial for cell adhesion, proliferation, and osteogenic differentiation. Results of in vivo analysis further indicated that PEEK-450 scaffolds exhibited preferential potential for bone ingrowth and vascular perfusion. Together, our findings support that porous PEEK implants designed with a suitable pore size and fabricated via three-dimensional printing constitute promising alternative biomaterials for bone grafting and tissue engineering applications with marked potential for clinical applications.

| S-EPMC7581231 | biostudies-literature

3D Printed Silicone Meniscus Implants: Influence of the 3D Printing Process on Properties of Silicone Implants.

Project description:Osteoarthritis of the knee with meniscal pathologies is a severe meniscal pathology suffered by the aging population worldwide. However, conventional meniscal substitutes are not 3D-printable and lack the customizability of 3D printed implants and are not mechanically robust enough for human implantation. Similarly, 3D printed hydrogel scaffolds suffer from drawbacks of being mechanically weak and as a result patients are unable to execute immediate post-surgical weight-bearing ambulation and rehabilitation. To solve this problem, we have developed a 3D silicone meniscus implant which is (1) cytocompatible, (2) resistant to cyclic loading and mechanically similar to native meniscus, and (3) directly 3D printable. The main focus of this study is to determine whether the purity, composition, structure, dimensions and mechanical properties of silicone implants are affected by the use of a custom-made in-house 3D-printer. We have used the phosphate buffer saline (PBS) absorption test, Fourier transform infrared (FTIR) spectroscopy, surface profilometry, thermo-gravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) to effectively assess and compare material properties between molded and 3D printed silicone samples.

| S-EPMC7570003 | biostudies-literature

The Surface Characterisation of Fused Filament Fabricated (FFF) 3D Printed PEEK/Hydroxyapatite Composites.

Project description:Polyetheretherketone (PEEK) is a high-performance thermoplastic polymer which has found increasing application in orthopaedics and has shown a lot of promise for 'made-to-measure' implants via additive manufacturing approaches. However, PEEK is bioinert and needs to undergo surface modification to make it at least osteoconductive to ensure a more rapid, improved, and stable fixation that will last longer in vivo. One approach to solving this issue is to modify PEEK with bioactive agents such as hydroxyapatite (HA). The work reported in this study demonstrates the direct 3D printing of PEEK/HA composites of up to 30 weight percent (wt%) HA using a Fused Filament Fabrication (FFF) approach. The surface characteristics and in vitro properties of the composite materials were investigated. X-ray diffraction revealed the samples to be semi-crystalline in nature, with X-ray Photoelectron Spectroscopy and Time-of-Flight Secondary Ion Mass Spectrometry revealing HA materials were available in the uppermost surface of all the 3D printed samples. In vitro testing of the samples at 7 days demonstrated that the PEEK/HA composite surfaces supported the adherence and growth of viable U-2 OS osteoblast like cells. These results demonstrate that FFF can deliver bioactive HA on the surface of PEEK bio-composites in a one-step 3D printing process.

| S-EPMC8471434 | biostudies-literature

3D-Printed Flat-Bone-Mimetic Bioceramic Scaffolds for Cranial Restoration.

Project description:The limitations of autologous bone grafts necessitate the development of advanced biomimetic biomaterials for efficient cranial defect restoration. The cranial bones are typical flat bones with sandwich structures, consisting of a diploe in the middle region and 2 outer compact tables. In this study, we originally developed 2 types of flat-bone-mimetic β-tricalcium phosphate bioceramic scaffolds (Gyr-Comp and Gyr-Tub) by high-precision vat-photopolymerization-based 3-dimensional printing. Both scaffolds had 2 outer layers and an inner layer with gyroid pores mimicking the diploe structure. The outer layers of Gyr-Comp scaffolds simulated the low porosity of outer tables, while those of Gyr-Tub scaffolds mimicked the tubular pore structure in the tables of flat bones. The Gyr-Comp and Gyr-Tub scaffolds possessed higher compressive strength and noticeably promoted in vitro cell proliferation, osteogenic differentiation, and angiogenic activities compared with conventional scaffolds with cross-hatch structures. After implantation into rabbit cranial defects for 12 weeks, Gyr-Tub achieved the best repairing effects by accelerating the generation of bone tissues and blood vessels. This work provides an advanced strategy to prepare biomimetic biomaterials that fit the structural and functional needs of efficacious bone regeneration.

| S-EPMC10603392 | biostudies-literature

3D-printed lightweight dorsal skin fold chambers from PEEK reduce chamber-related animal distress.

Project description:The dorsal skinfold chamber is one of the most important in vivo models for repetitive longitudinal assessment of microcirculation and inflammation. This study aimed to refine this model by introducing a new lightweight chamber made from polyetheretherketone (PEEK). Body weight, burrowing activity, distress, faecal corticosterone metabolites and the tilting angle of the chambers were analysed in mice carrying either a standard titanium chamber or a PEEK chamber. Data was obtained before chamber preparation and over a postoperative period of three weeks. In the early postoperative phase, reduced body weight and increased faecal corticosterone metabolites were found in mice with titanium chambers. Chamber tilting and tilting-related complications were reduced in mice with PEEK chambers. The distress score was significantly increased in both groups after chamber preparation, but only returned to preoperative values in mice with PEEK chambers. In summary, we have shown that light chambers reduce animal distress and may extend the maximum dorsal skinfold chamber observation time. Chambers made of PEEK are particularly suitable for this purpose: They are autoclavable, sufficiently stable to withstand rodent bites, inexpensive, and widely available through 3D printing.

| S-EPMC9270450 | biostudies-literature

Enhancing Supercapacitor Electrochemical Performance with 3D Printed Cellular PEEK/MWCNT Electrodes Coated with PEDOT: PSS.

Project description:In this study, we examine the electrochemical performance of supercapacitor (SC) electrodes made from 3D-printed nanocomposites. These composites consist of multiwalled carbon nanotubes (MWCNTs) and polyether ether ketone (PEEK), coated with poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS). The electrochemical performance of a 3D-printed PEEK/MWCNT solid electrode with a surface area density of 1.2 mm-1 is compared to two distinct periodically porous PEEK/MWCNT electrodes with surface area densities of 7.3 and 7.1 mm-1. To enhance SC performance, the 3D-printed electrodes are coated with a conductive polymer, PEDOT:PSS. The architected cellular electrodes exhibit significantly improved capacitive properties, with the cellular electrode (7.1 mm-1) displaying a capacitance nearly four times greater than that of the solid 3D-printed electrode-based SCs. Moreover, the PEDOT:PSS-coated cellular electrode (7.1 mm-1) demonstrates a high specific capacitance of 12.55 mF·cm-3 at 50 mV·s-1, contrasting to SCs based on 3D-printed cellular electrodes (4.09 mF·cm-3 at 50 mV·s-1) without the coating. The conductive PEDOT:PSS coating proves effective in reducing surface resistance, resulting in a decreased voltage drop during the SCs' charging and discharging processes. Ultimately, the 3D-printed cellular nanocomposite electrode with the conductive polymer coating achieves an energy density of 1.98 μW h·cm-3 at a current of 70 μA. This study underscores how the combined effect of the surface area density of porous electrodes enabled by 3D printing, along with the conductivity imparted by the polymer coating, synergistically improves the energy storage performance.

| S-EPMC11307982 | biostudies-literature

3D Printed Gene-activated Octacalcium Phosphate Implants for Large Bone Defects Engineering.

Project description:The aim of the study was the development of three-dimensional (3D) printed gene-activated implants based on octacalcium phosphate (OCP) and plasmid DNA encoding VEGFA. The first objective of the present work involved design and fabrication of gene-activated bone substitutes based on the OCP and plasmid DNA with VEGFA gene using 3D printing approach of ceramic constructs, providing the control of its architectonics compliance to the initial digital models. X-ray diffraction, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy, and compressive strength analyses were applied to investigate the chemical composition, microstructure, and mechanical properties of the experimental samples. The biodegradation rate and the efficacy of plasmid DNA delivery in vivo were assessed during standard tests with subcutaneous implantation to rodents in the next stage. The final part of the study involved substitution of segmental tibia and mandibular defects in adult pigs with 3D printed gene-activated implants. Biodegradation, osteointegration, and effectiveness of a reparative osteogenesis were evaluated with computerized tomography, SEM, and a histological examination. The combination of gene therapy and 3D printed implants manifested the significant clinical potential for effective bone regeneration in large/critical size defect cases.

| S-EPMC7557339 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data