Low risk of SARS-CoV-2 transmission via fomite, even in cold-chain.

ABSTRACT:

Background

Countries continue to debate the need for decontamination of cold-chain food packaging to reduce possible SARS-CoV-2 fomite transmission among workers. While laboratory-based studies demonstrate persistence of SARS-CoV-2 on surfaces, the likelihood of fomite-mediated transmission under real-life conditions is uncertain.

Methods

Using a quantitative risk assessment model, we simulated in a frozen food packaging facility 1) SARS-CoV-2 fomite-mediated infection risks following worker exposure to contaminated plastic packaging; and 2) reductions in these risks attributed to masking, handwashing, and vaccination.

Findings

In a representative facility with no specific interventions, SARS-CoV-2 infection risk to a susceptible worker from contact with contaminated packaging was 2·8 × 10 ^-3 per 1h-period (95%CI: 6·9 × 10 ^-6 , 2·4 × 10 ^-2 ). Implementation of standard infection control measures, handwashing and masks (9·4 × 10 ^-6 risk per 1h-period, 95%CI: 2·3 × 10 ^-8 , 8·1 × 10 ^-5 ), substantially reduced risk (99·7%). Vaccination of the susceptible worker (two doses Pfizer/Moderna, vaccine effectiveness: 86-99%) combined with handwashing and masking reduced risk to less than 1·0 × 10 ^-6 . Simulating increased infectiousness/transmissibility of new variants (2-, 10-fold viral shedding) among a fully vaccinated workforce, handwashing and masks continued to mitigate risk (2·0 × 10 ^-6 -1·1 × 10 ^-5 risk per 1h-period). Decontamination of packaging in addition to these interventions reduced infection risks to below the 1·0 × 10 ^-6 risk threshold.

Interpretation

Fomite-mediated SARS-CoV-2 infection risks were very low under cold-chain conditions. Handwashing and masking provide significant protection to workers, especially when paired with vaccination.

Funding

U.S. Department of Agriculture.

SUBMITTER: Sobolik JS 

PROVIDER: S-EPMC8404890 | biostudies-literature |

REPOSITORIES: biostudies-literature