Restrictive versus liberal transfusion thresholds in very low birth weight infants: A systematic review with meta-analysis.

ABSTRACT:

Background

To assess the efficacy and safety of restrictive versus liberal red blood cell transfusion thresholds in very low birth weight infants.

Methods

We searched MEDLINE, EMBASE, and Cochrane database without any language restrictions. The last search was conducted in August 15, 2020. All randomized controlled trials comparing the use of restrictive versus liberal red blood cell transfusion thresholds in very low birth weight (VLBW) infants were selected. Pooled risk ratio (RR) for dichotomous variable with 95% confidence intervals were assessed by a random-effects model. The primary outcome was all-cause mortality.

Results

Overall, this meta-analysis included 6 randomized controlled trials comprising 3,483 participants. Restrictive transfusion does not increase

SUBMITTER: Wang P 

PROVIDER: S-EPMC8405031 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature