Syndecan-1 and stromal heparan sulfate proteoglycans: key moderators of plasma cell biology and myeloma pathogenesis.
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ABSTRACT:
SUBMITTER: Ren Z
PROVIDER: S-EPMC8405055 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Publications
Syndecan-1 and stromal heparan sulfate proteoglycans: key moderators of plasma cell biology and myeloma pathogenesis.
Ren Zemin Z Spaargaren Marcel M Pals Steven T ST
Blood 20210401 13
Plasma cells no longer express a B-cell antigen receptor and are hence deprived of signals crucial for survival throughout B-cell development. Instead, normal plasma cells, as well as their malignant myeloma counterparts, heavily rely on communication with the bone marrow (BM) microenvironment for survival. The plasma cell heparan sulfate proteoglycan (HSPG) syndecan-1 (CD138) and HSPGs in the BM microenvironment act as master regulators of this communication by co-opting specific growth and sur ...[more]
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