Ontology highlight
ABSTRACT:
SUBMITTER: Kamasaki T
PROVIDER: S-EPMC8405961 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Kamasaki Tomoko T Miyazaki Yumi Y Ishikawa Susumu S Hoshiba Kazuya K Kuromiya Keisuke K Tanimura Nobuyuki N Mori Yusuke Y Tsutsumi Motosuke M Nemoto Tomomi T Uehara Ryota R Suetsugu Shiro S Itoh Toshiki T Fujita Yasuyuki Y
iScience 20210818 9
At the initial stage of carcinogenesis, cell competition often occurs between newly emerging transformed cells and the neighboring normal cells, leading to the elimination of transformed cells from the epithelial layer. For instance, when RasV12-transformed cells are surrounded by normal cells, RasV12 cells are apically extruded from the epithelium. However, the underlying mechanisms of this tumor-suppressive process still remain enigmatic. We first show by electron microscopic analysis that cha ...[more]