Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer.

ABSTRACT: Bone metastasis is an incurable complication of breast cancer. In advanced stages, patients with estrogen-positive tumors experience a significantly higher incidence of bone metastasis (>87%) compared to estrogen-negative patients (<56%). To understand the mechanism of this bone-tropism of ER⁺ tumor, and to identify liquid biopsy biomarkers for patients with high risk of bone metastasis, the secreted extracellular vesicles and cytokines from bone-tropic breast cancer cells are examined in this study. Both exosomal miR-19a and Integrin-Binding Sialoprotein (IBSP) are found to be significantly upregulated and secreted from bone-tropic ER⁺ breast cancer cells, increasing their levels in the circulation of patients. IBSP is found to attract osteoclast cells and create an

SUBMITTER: Wu K 

PROVIDER: S-EPMC8408156 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature