IL27 T4730C Polymorphism and Serology in Multiple Sclerosis: A Pilot Study.

ABSTRACT:

Background

Multiple sclerosis (MS) is one of the most debilitating neurological diseases of young adults. The presence of a single nucleotide polymorphism in the promoter regions of the interleukin 27 gene (IL27 T4730C, rs181206) may alter the transcription and the production of cytokine levels, leading to MS.

Patients and methods

We performed a case-control study including 82 individuals: 51 patients diagnosed with MS and 31 healthy controls. Polymerase chain reaction-restriction fragment length polymorphism was used in order to determine the genotypes for the IL27 T4730С polymorphism and enzyme-linked immunosorbent assay to measure the serum IL27 level.

Results

Carriers of the T4730С polymorphism were found to have a 6-fold [95% confidence intervaI (CI)=1.83-19.63,

SUBMITTER: Barac IS 

PROVIDER: S-EPMC8408743 | biostudies-literature | 2021 Sep-Oct

REPOSITORIES: biostudies-literature