Dataset Information

Anti-CD74 IgA autoantibodies in radiographic axial spondyloarthritis; a longitudinal Swedish study.

ABSTRACT:

Objectives

Antibodies against anti-CD74 are related to axial spondyloarthritis (axSpA). The objectives were to study; 1) IgA anti-CD74 in radiographic (r)-axSpA patients in the Backbone cohort and to calculate the sensitivity and specificity of anti-CD74, 2) the fluctuation of IgA anti-CD74 levels in prospectively collected samples, 3) and to explore the relation between IgA anti-CD74 and radiographic spinal changes.

Methods

IgA anti-CD74 was analyzed by ELISA in 155 patients with r-axSpA and age- and sex-matched controls. BASDAI, ASDAS, BASFI, and BASMI were assessed and spinal radiographs were scored for r-axSpA related changes with mSASSS. Previously donated samples, before inclusion in the Backbone study, were identified in the Medical Biobank of Northern Sweden.

Results

A total of 155 patients comprising 69% men and 31% women, age (mean±SD) 55.5 ± 11.4 years, and 152 (98.1%) HLA-B27 positive, were included. The plasma level of IgA anti-CD74 was significantly higher in the patients, median (IQR), 12.9 (7.9-17.9) U/ml compared with controls 10.9 (7.2-14.6) U/ml, p= 0.003. IgA anti-CD74 was above the cut-off level of 20 U/ml in 36/155 (23.2%) patients and in 15/151 (9.9%) controls, p= 0.002. Multivariable logistic regression analyzes revealed that to have ≥1 syndesmophyte associated with IgA anti-CD74 (OR 5.64, 95% CI, 1.02-35.58, p= 0.048) adjusted for hsCRP, smoking, BMI, sex, and age. No distinct pattern of IgA anti-CD74 over time was revealed.

Conclusion

Plasma levels of IgA anti-CD74 were increased in r-axSpA and independently associated with radiographic spinal changes which suggests that IgA anti-CD74 could play a role in the pathogenies of r-axSpA.

SUBMITTER: Do L

PROVIDER: S-EPMC8410007 | biostudies-literature |

REPOSITORIES: biostudies-literature

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