Proteomics

Dataset Information

0

Proteomics analysis of plasma from radiographic axial spondyloarthritis patients.


ABSTRACT: Tandem mass spectrometry analysis of proteins from depleted plasma from radiographic axial spondyloarthritis patients pre- and post-treated with adalimumab.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: Jean ARMENGAUD  

LAB HEAD: Jean Armengaud

PROVIDER: PXD026189 | Pride | 2024-05-02

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
F215666.dat Other
F215666_p0.05.mzid.gz Mzid
F215667.dat Other
F215667_p0.05.mzid.gz Mzid
F215668.dat Other
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Publications


This study aims at identifying molecular biomarkers differentiating responders and non-responders to treatment with Tumor Necrosis Factor inhibitors (TNFi) among patients with axial spondyloarthritis (axSpA). Whole blood mRNA and plasma proteins were measured in a cohort of biologic-naïve axSpA patients (<i>n</i> = 35), pre and post (14 weeks) TNFi treatment with adalimumab. Differential expression analysis was used to identify the most enriched pathways and in predictive models to distinguish r  ...[more]

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