Ontology highlight
ABSTRACT: Purpose
The tumor-infiltrating lymphocytes (TILs) expression in breast cancer is a positive prognostic marker for certain breast cancer subtypes. We evaluated the efficacy of dual anti-human epidermal growth factor receptor 2 (HER2) blockade in HER2-positive breast cancer and hypothesized that high TILs tumors are associated with better outcomes.Methods
A total of 176 patients who were treated with neoadjuvant docetaxel, carboplatin, trastuzumab, and pertuzumab (TCHP) between December 2015 and December 2018 were reviewed. They were grouped based on a cut-off value of the stromal TILs grade (≤ 20% TILs, > 20% TILs).Results
In total, 107 patients (60.8%) achieved pathological complete response (pCR). Hormone receptor (HR)-negativity (p = 0.001) and a high TILs grade (p = 0.022) were independent predictors of pCR. Among the HR-negative patients, high TILs tumors were significantly associated with pCR (p = 0.035).Conclusion
HR status and the TILs grade are significantly correlated with pCR in dual anti-HER2 neoadjuvant therapy. The evaluation of the TILs at baseline may be beneficial for predicting pCR in HER2-positive breast cancer.
SUBMITTER: Ha JY
PROVIDER: S-EPMC8410619 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Ha Joo Young JY Kim Jeong Eun JE Lee Hee Jin HJ Jeong Jae Ho JH Ahn Jin-Hee JH Jung Kyung Hae KH Gong Gyungyub G Chae Eun Young EY Kim Hak Hee HH Chung Il Yong IY Ko Beom Seok BS Kim Sung-Bae SB
Journal of breast cancer 20210709 4
<h4>Purpose</h4>The tumor-infiltrating lymphocytes (TILs) expression in breast cancer is a positive prognostic marker for certain breast cancer subtypes. We evaluated the efficacy of dual anti-human epidermal growth factor receptor 2 (HER2) blockade in HER2-positive breast cancer and hypothesized that high TILs tumors are associated with better outcomes.<h4>Methods</h4>A total of 176 patients who were treated with neoadjuvant docetaxel, carboplatin, trastuzumab, and pertuzumab (TCHP) between Dec ...[more]