Combinational blockade of MET and PD-L1 improves pancreatic cancer immunotherapeutic efficacy.

ABSTRACT:

Background

Dysregulated expression and activation of receptor tyrosine kinases (RTKs) are associated with a range of human cancers. However, current RTK-targeting strategies exert little effect on pancreatic cancer, a highly malignant tumor with complex immune microenvironment. Given that immunotherapy for pancreatic cancer still remains challenging, this study aimed to elucidate the prognostic role of RTKs in pancreatic tumors with different immunological backgrounds and investigate their targeting potential in pancreatic cancer immunotherapy.

Methods

Kaplan-Meier plotter was used to analyze the prognostic significance of each of the all-known RTKs to date in immune "hot" and "cold" pancreatic cancers. Gene Expression Profiling Interactive Analysis-2 was applied to assess t

SUBMITTER: Li E 

PROVIDER: S-EPMC8414725 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature