Risk factors for early-onset colorectal cancer: a population-based case-control study in Ontario, Canada.

ABSTRACT:

Purpose

There has been an alarming increase in colorectal cancer (CRC) incidence among young adults aged < 50 years, and factors driving this upward trend are unknown. This study investigated associations between various medical, lifestyle, and dietary factors and risk of early-onset CRC (EO-CRC).

Methods

A population-based case-control study was conducted in Ontario, Canada during 2018-2019. EO-CRC cases aged 20-49 years (n = 175) were identified from the Ontario Cancer Registry; sex- and age group-matched controls (n = 253) were recruited through random digit dialing. Data on potential a priori risk factors were collected using a web-based self-reported questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable logistic regression.

SUBMITTER: Chang VC 

PROVIDER: S-EPMC8416813 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature