Reproductive Factors and Colorectal Cancer Risk: A Population-Based Case-Control Study.

ABSTRACT:

Background

Hormone-replacement therapy (HRT) is associated with lower colorectal cancer (CRC) risk among postmenopausal women. However, little is known about the effects of lifetime exposure of women to varying levels of estrogen and progesterone through reproductive factors such as parity, use of oral contraceptives (OC), breastfeeding, and menstruation on CRC risk.

Methods

We assessed associations between reproductive factors and CRC risk among 2650 female CRC patients aged 30+ years and 2175 matched controls in a population-based study in Germany, adjusting for potential confounders by multiple logistic regression.

Results

Inverse associations with CRC risk were found for numbers of pregnancies (odds ratio [OR] per pregnancy = 0.91, 95% confidence interval [CI] = 0

SUBMITTER: Amitay EL 

PROVIDER: S-EPMC9251386 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature