Ontology highlight
ABSTRACT:
SUBMITTER: Dong C
PROVIDER: S-EPMC8417031 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Dong Caihua C Li Xinying X Yang Jiao J Yuan Detian D Zhou Yuanshuai Y Zhang Yina Y Shi Guohua G Zhang Ruobing R Liu Jianping J Fu Peng P Sun Minxuan M
Cell death & disease 20210903 9
Glioblastoma multiforme (GBM) is the most aggressive brain tumor, with a 5-year survival ratio <5%. Invasive growth is a major determinant of the poor prognosis in GBM. In this study, we demonstrate that high expression of PPFIA binding protein 1 (PPFIBP1) correlates with remarkable invasion and poor prognosis of GBM patients. Using scratch and transwell assay, we find that the invasion and migration of GBM cells are promoted by overexpression of PPFIBP1, while inhibited by knockdown of PPFIBP1. ...[more]