Ontology highlight
ABSTRACT:
SUBMITTER: Padhi AK
PROVIDER: S-EPMC8426738 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Padhi Aditya K AK Dandapat Jagneshwar J Saudagar Prakash P Uversky Vladimir N VN Tripathi Timir T
FEBS letters 20210901 18
Favipiravir is a broad-spectrum inhibitor of viral RNA-dependent RNA polymerase (RdRp) currently being used to manage COVID-19. Accumulation of mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RdRp may facilitate antigenic drift, generating favipiravir resistance. Focussing on the chain-termination mechanism utilized by favipiravir, we used high-throughput interface-based protein design to generate > 100 000 designs of the favipiravir-binding site of RdRp and identify mu ...[more]