Ontology highlight
ABSTRACT:
SUBMITTER: Yang B
PROVIDER: S-EPMC8429505 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Yang Bo B Zhang Ge G Qin Xiao X Huang Yulu Y Ren Xiaowen X Sun Jingliang J Ma Shujun S Liu Yanzi Y Song Di D Liu Yue Y Cui Yuhan Y Wang Hui H Wang Jie J
Frontiers in immunology 20210827
The antiviral innate immunity is the first line of host defense against viral infection. Mitochondrial antiviral signaling protein (MAVS, also named Cardif/IPS-1/VISA) is a critical protein in RNA virus-induced antiviral signaling pathways. Our previous research suggested that E3 ubiquitin-protein ligases RING-finger protein (RNF90) negatively regulate cellular antiviral responses by targeting STING for degradation, though its role in RNA virus infection remains unknown. This study demonstrated ...[more]