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Numerical modeling of ultrasonic cavitation by dividing coated microbubbles into groups.

ABSTRACT: Homogeneous cavitation models usually use an average radius to predict the dynamics of all bubbles. However, bubbles with different sizes may have quite different dynamic characteristics. In this study, the bubbles are divided into several groups by size, and the volume-weighted average radius is used to separately calculate the dynamics of each group using a modified bubble dynamics equation. In the validation part, the oscillations of bubbles with two sizes are simulated by dividing them into 2 groups. Comparing with the predictions by the Volume of Fluid (VOF) method, the bubble dynamics of each size are precisely predicted by the proposed model. Then coated microbubbles with numerous sizes are divided into several groups in equal quantity, and the influence of the group number is analyzed. For bubble oscillations at f = 0.1 MHz and 1 MHz without ruptures, the oscillation amplitude is obviously under-estimated by the 1-group model, while they are close to each other after the group number increases to 9. For bubble ruptures triggered by Gaussian pulses, the predictions are close to each other when more than 5 groups are used.

SUBMITTER: Ye Y

PROVIDER: S-EPMC8430393 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Numerical modeling of ultrasonic cavitation by dividing coated microbubbles into groups.

Ye Yanghui Y Liang Yangyang Y Dong Cong C Bu Zhongming Z Li Guoneng G Zheng Youqu Y

Ultrasonics sonochemistry 20210826

Homogeneous cavitation models usually use an average radius to predict the dynamics of all bubbles. However, bubbles with different sizes may have quite different dynamic characteristics. In this study, the bubbles are divided into several groups by size, and the volume-weighted average radius is used to separately calculate the dynamics of each group using a modified bubble dynamics equation. In the validation part, the oscillations of bubbles with two sizes are simulated by dividing them into ...[more]

PMID: 34500314

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Project description:ObjectivesUltrasound-mediated gene delivery can be amplified by acoustic disruption of microbubble carriers that undergo cavitation. We hypothesized that endothelial targeting of microbubbles bearing cDNA is feasible and, through optimizing proximity to the vessel wall, increases the efficacy of gene transfection.BackgroundContrast ultrasound-mediated gene delivery is a promising approach for site-specific gene therapy, although there are concerns with the reproducibility of this technique and the safety when using high-power ultrasound.MethodsCationic lipid-shelled decafluorobutane microbubbles bearing a targeting moiety were prepared and compared with nontargeted microbubbles. Microbubble targeting efficiency to endothelial adhesion molecules (P-selectin or intercellular adhesion molecule [ICAM]-1) was tested using in vitro flow chamber studies, intravital microscopy of tumor necrosis factor-alpha (TNF-α)-stimulated murine cremaster muscle, and targeted contrast ultrasound imaging of P-selectin in a model of murine limb ischemia. Ultrasound-mediated transfection of luciferase reporter plasmid charge coupled to microbubbles in the post-ischemic hindlimb muscle was assessed by in vivo optical imaging.ResultsCharge coupling of cDNA to the microbubble surface was not influenced by the presence of targeting ligand, and did not alter the cavitation properties of cationic microbubbles. In flow chamber studies, surface conjugation of cDNA did not affect attachment of targeted microbubbles at microvascular shear stresses (0.6 and 1.5 dyne/cm(2)). Attachment in vivo was also not affected by cDNA according to intravital microscopy observations of venular adhesion of ICAM-1-targeted microbubbles and by ultrasound molecular imaging of P-selectin-targeted microbubbles in the post-ischemic hindlimb in mice. Transfection at the site of high acoustic pressures (1.0 and 1.8 MPa) was similar for control and P-selectin-targeted microbubbles but was associated with vascular rupture and hemorrhage. At 0.6 MPa, there were no adverse bioeffects, and transfection was 5-fold greater with P-selectin-targeted microbubbles.ConclusionsWe conclude that ultrasound-mediated transfection at safe acoustic pressures can be markedly augmented by endothelial juxtaposition.

Dataset Information

Numerical modeling of ultrasonic cavitation by dividing coated microbubbles into groups.

Publications

Numerical modeling of ultrasonic cavitation by dividing coated microbubbles into groups.

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