Role of EphA4 in Mediating Motor Neuron Death in MND.
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ABSTRACT:
SUBMITTER: Zhao J
PROVIDER: S-EPMC8430883 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Publications
Role of EphA4 in Mediating Motor Neuron Death in MND.
Zhao Jing J Stevens Claire H CH Boyd Andrew W AW Ooi Lezanne L Bartlett Perry F PF
International journal of molecular sciences 20210830 17
Motor neuron disease (MND) comprises a group of fatal neurodegenerative diseases with no effective cure. As progressive motor neuron cell death is one of pathological characteristics of MND, molecules which protect these cells are attractive therapeutic targets. Accumulating evidence indicates that EphA4 activation is involved in MND pathogenesis, and inhibition of EphA4 improves functional outcomes. However, the underlying mechanism of EphA4's function in MND is unclear. In this review, we firs ...[more]
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