Ontology highlight
ABSTRACT:
SUBMITTER: Dupuis L
PROVIDER: S-EPMC2206606 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Dupuis Luc L Pehar Mariana M Cassina Patricia P Rene Frédérique F Castellanos Raquel R Rouaux Caroline C Gandelman Mandi M Dimou Leda L Schwab Martin E ME Loeffler Jean-Philippe JP Barbeito Luis L Gonzalez de Aguilar Jose-Luis JL
Proceedings of the National Academy of Sciences of the United States of America 20080108 2
The Nogo-66 receptor (NgR) plays a critical role in restricting axon regeneration in the central nervous system. This inhibitory action is in part mediated by a neuronal receptor complex containing p75NTR, a multifunctional receptor also well known to trigger cell death upon binding to neurotrophins such as NGF. In the present study, we show that Pep4 and NEP1-40, which are two peptides derived from the Nogo-66 sequence that modulate NgR-mediated neurite outgrowth inhibition, prevent NGF-stimula ...[more]