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Nogo receptor antagonizes p75NTR-dependent motor neuron death.


ABSTRACT: The Nogo-66 receptor (NgR) plays a critical role in restricting axon regeneration in the central nervous system. This inhibitory action is in part mediated by a neuronal receptor complex containing p75NTR, a multifunctional receptor also well known to trigger cell death upon binding to neurotrophins such as NGF. In the present study, we show that Pep4 and NEP1-40, which are two peptides derived from the Nogo-66 sequence that modulate NgR-mediated neurite outgrowth inhibition, prevent NGF-stimulated p75NTR-dependent death of cultured embryonic motor neurons. They also confer protection on spinal cord motor neurons after neonatal sciatic nerve axotomy. These findings demonstrate an as-yet-unknown function of NgR in maintaining neuronal survival that may be relevant for motor neuron development and degeneration.

SUBMITTER: Dupuis L 

PROVIDER: S-EPMC2206606 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature

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Nogo receptor antagonizes p75NTR-dependent motor neuron death.

Dupuis Luc L   Pehar Mariana M   Cassina Patricia P   Rene Frédérique F   Castellanos Raquel R   Rouaux Caroline C   Gandelman Mandi M   Dimou Leda L   Schwab Martin E ME   Loeffler Jean-Philippe JP   Barbeito Luis L   Gonzalez de Aguilar Jose-Luis JL  

Proceedings of the National Academy of Sciences of the United States of America 20080108 2


The Nogo-66 receptor (NgR) plays a critical role in restricting axon regeneration in the central nervous system. This inhibitory action is in part mediated by a neuronal receptor complex containing p75NTR, a multifunctional receptor also well known to trigger cell death upon binding to neurotrophins such as NGF. In the present study, we show that Pep4 and NEP1-40, which are two peptides derived from the Nogo-66 sequence that modulate NgR-mediated neurite outgrowth inhibition, prevent NGF-stimula  ...[more]

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