Delivery of Metabolically Neuroactive Probiotics to the Human Gut.

ABSTRACT: The human microbiome is a rich factory for metabolite production and emerging data has led to the concept that orally administered microbial strains can synthesize metabolites with neuroactive potential. Recent research from ex vivo and murine models suggests translational potential for microbes to regulate anxiety and depression through the gut-brain axis. However, so far, less emphasis has been placed on the selection of specific microbial strains known to produce the required key metabolites and the formulation in which microbial compositions are delivered to the gut. Here, we describe a double-capsule technology to deliver high numbers of metabolically active cells derived from the 24-strain probiotic product SH-DS01 to the gastrointestinal tract, including the small intestine,

SUBMITTER: Bron PA 

PROVIDER: S-EPMC8431588 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature