Shikonin induces programmed death of fibroblast synovial cells in rheumatoid arthritis by inhibiting energy pathways.
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ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC8440543 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
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Shikonin induces programmed death of fibroblast synovial cells in rheumatoid arthritis by inhibiting energy pathways.
Li Jiahui J Pang Jinglong J Liu Zhe Z Ge XianMing X Zhen Yanan Y Jiang Chen Chen CC Liu Yaming Y Huo Qiang Q Sun Yiming Y Liu Hao H
Scientific reports 20210914 1
Shikonin is the main component of the traditional Chinese medicine comfrey, which can inhibit the activity of PKM2 by regulating glycolysis and ATP production. Rheumatoid arthritis synovial cells (RA-FLSs) have been reported to increase glycolytic activity and have other similar hallmarks of metabolic activity. In this study, we investigated the effects of shikonin on glycolysis, mitochondrial function, and cell death in RA-FLSs. The results showed that shikonin induced apoptosis and autophagy i ...[more]
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