Microglia promote autoimmune inflammation via the noncanonical NF-κB pathway.
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ABSTRACT:
SUBMITTER: Jie Z
PROVIDER: S-EPMC8442891 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
Microglia promote autoimmune inflammation via the noncanonical NF-κB pathway.
Jie Zuliang Z Ko Chun-Jung CJ Wang Hui H Xie Xiaoping X Li Yanchuan Y Gu Meidi M Zhu Lele L Yang Jin-Young JY Gao Tianxiao T Ru Wenjuan W Tang Shao-Jun SJ Cheng Xuhong X Sun Shao-Cong SC
Science advances 20210903 36
Microglia have been implicated in neuroinflammatory diseases, including multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE). We demonstrate that microglia mediate EAE disease progression via a mechanism relying on the noncanonical nuclear factor kB (NF-κB) pathway. Microglia-specific deletion of the noncanonical NF-κB-inducing kinase (NIK) impairs EAE disease progression. Although microglial NIK is dispensable for the initial phase of T cell infiltration into ...[more]
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