Ontology highlight
ABSTRACT:
SUBMITTER: Wang P
PROVIDER: S-EPMC8444215 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Wang Peng P Zhao Jing J Hossaini Nasr Seyedmehdi S Otieno Sarah A SA Zhang Fuming F Qiang Wei W Linhardt Robert J RJ Huang Xuefei X
ACS chemical biology 20210216 10
Heparan sulfate (HS) can play important roles in the biology and pathology of amyloid β (Aβ), a hallmark of Alzheimer's disease. To better understand the structure-activity relationship of HS/Aβ interactions, synthetic HS oligosaccharides ranging from tetrasaccharides to decasaccharides have been utilized to study Aβ interactions. Surface plasmon resonance experiments showed that the highly sulfated HS tetrasaccharides bearing full 2-<i>O</i>, 6-<i>O</i>, and <i>N</i>-sulfations exhibited the st ...[more]