Unknown

Dataset Information

0

Insulin-like growth factor binding protein-1 regulates HIF-1α degradation to inhibit apoptosis in hypoxic cardiomyocytes.


ABSTRACT: Hypoxia is important in ischemic heart disease. Excessive Insulin-like growth factor binding protein-1 (IGFBP-1) amounts are considered to harm cardiomyocytes in acute myocardial infarction. However, the mechanisms by which IGFBP-1 affects cardiomyocytes remain undefined. The present study demonstrated that hypoxia up-regulates IGFBP-1 and HIF-1α protein expression in cardiomyocytes. Subsequent assays showed that IGFBP-1 suppression decreased HIF-1α expression and inhibited hypoxia-induced apoptosis in cardiomyocytes, which was reversed by HIF-1α overexpression, indicating that HIF-1α is essential to IGFBP-1 function in cellular apoptosis. In addition, we showed that IGFBP-1 regulated HIF-1α stabilization through interacting with VHL. The present findings suggest that IGFBP-1-HIF-1α could be targeted for treating ischemic heart disease.

SUBMITTER: Tang X 

PROVIDER: S-EPMC8445926 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC5703960 | biostudies-literature
| S-EPMC3367222 | biostudies-literature
| S-EPMC4304203 | biostudies-literature
| S-EPMC5171868 | biostudies-literature
| S-EPMC9898070 | biostudies-literature
| S-EPMC4560388 | biostudies-literature
| S-EPMC6686016 | biostudies-literature
| S-EPMC6123950 | biostudies-literature
| S-EPMC4637857 | biostudies-other
| S-EPMC5604011 | biostudies-literature