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Clarifying the Implicit Assumptions of Two-Wave Mediation Models via the Latent Change Score Specification: An Evaluation of Model Fit Indices.

ABSTRACT: Statistical mediation analysis is used to investigate mechanisms through which a randomized intervention causally affects an outcome variable. Mediation analysis is often carried out in a pretest-posttest control group design because it is a common choice for evaluating experimental manipulations in the behavioral and social sciences. There are four different two-wave (i.e., pretest-posttest) mediation models that can be estimated using either linear regression or a Latent Change Score (LCS) specification in Structural Equation Modeling: Analysis of Covariance, difference and residualized change scores, and a cross-sectional model. Linear regression modeling and the LCS specification of the two-wave mediation models provide identical mediated effect estimates but the two modeling approaches differ in their assumptions of model fit. Linear regression modeling assumes each of the four two-wave mediation models fit the data perfectly whereas the LCS specification allows researchers to evaluate the model constraints implied by the difference score, residualized change score, and cross-sectional models via model fit indices. Therefore, the purpose of this paper is to provide a conceptual and statistical comparison of two-wave mediation models. Models were compared on the assumptions they make about time-lags and cross-lagged effects as well as statistically using both standard measures of model fit (χ², RMSEA, and CFI) and newly proposed T-size measures of model fit for the two-wave mediation models. Overall, the LCS specification makes clear the assumptions that are often implicitly made when fitting two-wave mediation models with regression. In a Monte Carlo simulation, the standard model fit indices and newly proposed T-size measures of model fit generally correctly identified the best fitting two-wave mediation model.

SUBMITTER: Valente MJ

PROVIDER: S-EPMC8450329 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:BackgroundThere is evidence that slow wave sleep (SWS) promotes the consolidation of memories that are subserved by mediotemporal- and hippocampo-cortical neural networks. In contrast to implicit memories, explicit memories are accompanied by conscious (attentive and controlled) processing. Awareness at pre-sleep encoding has been recognized as critical for the off-line memory consolidation. The present study elucidated the role of task-dependent cortical activation guided by attentional control at pre-sleep encoding for the consolidation of hippocampus-dependent memories during sleep.MethodologyA task with a hidden regularity was used (Number Reduction Task, NRT), in which the responses that can be implicitly predicted by the hidden regularity activate hippocampo-cortical networks more strongly than responses that cannot be predicted. Task performance was evaluated before and after early-night sleep, rich in SWS, and late-night sleep, rich in rapid eye movement (REM) sleep. In implicit conditions, slow cortical potentials (SPs) were analyzed to reflect the amount of controlled processing and the localization of activated neural task representations.Principal findingsDuring implicit learning before sleep, the amount of controlled processing did not differ between unpredictable and predictable responses, nor between early- and late-night sleep groups. A topographic re-distribution of SPs indicating a spatial reorganization occurred only after early, not after late sleep, and only for predictable responses. These SP changes correlated with the amount of SWS and were covert because off-line RT decrease did not differentiate response types or sleep groups.ConclusionsIt is concluded that SWS promotes the neural reorganization of task representations that rely on the hippocampal system despite absence of conscious access to these representations.SignificanceOriginal neurophysiologic evidence is provided for the role of SWS in the consolidation of memories encoded with hippocampo-cortical interaction before sleep. It is demonstrated that this SWS-mediated mechanism does not depend critically on explicitness at learning nor on the amount of controlled executive processing during pre-sleep encoding.

Dataset Information

Clarifying the Implicit Assumptions of Two-Wave Mediation Models via the Latent Change Score Specification: An Evaluation of Model Fit Indices.

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