Ontology highlight
ABSTRACT:
SUBMITTER: Patel O
PROVIDER: S-EPMC8452690 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Patel Onisha O Roy Michael J MJ Kropp Ashleigh A Hardy Joshua M JM Dai Weiwen W Lucet Isabelle S IS
Communications biology 20210920 1
Doublecortin-like kinase 1 (DCLK1) is an understudied bi-functional kinase with a proven role in tumour growth and development. However, the presence of tissue-specific spliced DCLK1 isoforms with distinct biological functions have challenged the development of effective strategies to understand the role of DCLK1 in oncogenesis. Recently, DCLK1-IN-1 was reported as a highly selective DCLK1 inhibitor, a powerful tool to dissect DCLK1 biological functions. Here, we report the crystal structures of ...[more]