Unknown

Dataset Information

0

B cells promote CD8 T cell primary and memory responses to subunit vaccines.


ABSTRACT: The relationship between B cells and CD4 T cells has been carefully studied, revealing a collaborative effort in which B cells promote the activation, differentiation, and expansion of CD4 T cells while the so-called "helper" cells provide signals to B cells, influencing their class switching and fate. Interactions between B cells and CD8 T cells are not as well studied, although CD8 T cells exhibit an accelerated contraction after certain infections in B-cell-deficient mice. Here, we find that B cells significantly enhance primary CD8 T cell responses after vaccination. Moreover, memory CD8 numbers and function are impaired in B-cell-deficient animals, leading to increased susceptibility to bacterial challenge. We also show that interleukin-27 production by B cells contributes to their impact on primary, but not memory, CD8 responses. Better understanding of the interactions between CD8 T cells and B cells may aid in the design of more effective future vaccine strategies.

SUBMITTER: Klarquist J 

PROVIDER: S-EPMC8456706 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC1637592 | biostudies-literature
| S-EPMC3359346 | biostudies-literature
| S-EPMC1950948 | biostudies-literature
| S-EPMC2836785 | biostudies-literature
| S-EPMC4449618 | biostudies-literature
| S-EPMC10153284 | biostudies-literature
| S-EPMC6289779 | biostudies-literature
| S-EPMC4710197 | biostudies-literature
| S-EPMC2789207 | biostudies-literature
| S-EPMC5444865 | biostudies-literature