The Human Hippocampus in Parkinson's Disease: An Integrative Stereological and Proteomic Study.

ABSTRACT:

Background

Parkinson's disease (PD) is a prevalent neurodegenerative disease that is pathologically described as a six-stage α-synucleinopathy. In stage 4, α-synuclein reaches the hippocampus, inducing cognitive deficits, from which it progresses to the isocortex, leading to dementia. Among hippocampal fields, cornu ammonis 2 is particularly affected by this α-synucleinopathy and critical for cognitive decline. Volumetric studies using magnetic resonance imaging have produced controversial results, with only some reporting volume loss, whereas stereological data obtained using nonspecific markers do not reveal volume changes, neural or glial loss. Proteomic analysis has not been carried out in the hippocampus of patients with PD.

Objective

This study aims to explain hippocam

SUBMITTER: Villar-Conde S 

PROVIDER: S-EPMC8461741 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature