Dataset Information
Randomized Trial of Irinotecan and Cetuximab With or Without Vemurafenib in BRAF-Mutant Metastatic Colorectal Cancer (SWOG S1406).
Ontology highlight
ABSTRACT: Purpose
BRAFV600E mutations are rarely associated with objective responses to the BRAF inhibitor vemurafenib in patients with metastatic colorectal cancer (CRC). Blockade of BRAFV600E by vemurafenib causes feedback upregulation of EGFR, whose signaling activities can be impeded by cetuximab.Methods
One hundred six patients with BRAFV600E-mutated metastatic CRC previously treated with one or two regimens were randomly assigned to irinotecan and cetuximab with or without vemurafenib (960 mg PO twice daily).Results
Progression-free survival, the primary end point, was improved with the addition of vemurafenib (hazard ratio, 0.50, P = .001). The response rate was 17% versus 4% (P = .05), with a disease control rate of 65% versus 21% (P < .001). A decline in circulating tumor DNA BRAFV600E variant allele frequency was seen in 87% versus 0% of patients (P < .001), with a low incidence of acquired RAS alterations at the time of progression. RNA profiling suggested that treatment benefit did not depend on previously established BRAF subgroups or the consensus molecular subtype.Conclusion
Simultaneous inhibition of EGFR and BRAF combined with irinotecan is effective in BRAFV600E-mutated CRC.
SUBMITTER: Kopetz S
PROVIDER: S-EPMC8462593 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Randomized Trial of Irinotecan and Cetuximab With or Without Vemurafenib in BRAF-Mutant Metastatic Colorectal Cancer (SWOG S1406).
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20201223 4
<h4>Purpose</h4><i>BRAF</i><sup><i>V600E</i></sup> mutations are rarely associated with objective responses to the BRAF inhibitor vemurafenib in patients with metastatic colorectal cancer (CRC). Blockade of <i>BRAF</i><sup><i>V600E</i></sup> by vemurafenib causes feedback upregulation of EGFR, whose signaling activities can be impeded by cetuximab.<h4>Methods</h4>One hundred six patients with <i>BRAF</i><sup><i>V600E</i></sup>-mutated metastatic CRC previously treated with one or two regimens we ...[more]
