Ontology highlight
ABSTRACT:
SUBMITTER: Rutherford TR
PROVIDER: S-EPMC8463677 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Rutherford Taylor R TR Elder Alan M AM Lyons Traci R TR
Cell death & disease 20210924 10
Semaphorin-7a (SEMA7A), best known as a neuroimmune molecule, plays a diverse role in many cellular processes and pathologies. Here, we show that SEMA7A promotes anoikis resistance in cultured mammary epithelial cells through integrins and activation of pro-survival kinase AKT, which led us to investigate a role for SEMA7A during postpartum mammary gland involution-a normal developmental process where cells die by anoikis. Our results reveal that SEMA7A is expressed on live mammary epithelial ce ...[more]