The HIV-1 capsid and reverse transcription.
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ABSTRACT:
SUBMITTER: Aiken C
PROVIDER: S-EPMC8466977 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
The HIV-1 capsid and reverse transcription.
Aiken Christopher C Rousso Itay I
Retrovirology 20210925 1
The viral capsid plays a key role in HIV-1 reverse transcription. Recent studies have demonstrated that the small molecule IP6 dramatically enhances reverse transcription in vitro by stabilizing the viral capsid. Reverse transcription results in marked changes in the biophysical properties of the capsid, ultimately resulting in its breakage and disassembly. Here we review the research leading to these advances and describe hypotheses for capsid-dependent HIV-1 reverse transcription and a model f ...[more]
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