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Advances in understanding the initiation of HIV-1 reverse transcription.

ABSTRACT: Many viruses, including Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Human Immunodeficiency Virus (HIV), use RNA as their genetic material. How viruses harness RNA structure and RNA-protein interactions to control their replication remains obscure. Recent advances in the characterization of HIV-1 reverse transcriptase, the enzyme that converts its single-stranded RNA genome into a double-stranded DNA copy, reveal how the reverse transcription complex evolves during initiation. Here we highlight these advances in HIV-1 structural biology and discuss how they are furthering our understanding of HIV and related ribonucleoprotein complexes implicated in viral disease.

SUBMITTER: Krupkin M

PROVIDER: S-EPMC9973426 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Advances in understanding the initiation of HIV-1 reverse transcription.

Krupkin Miri M Jackson Lynnette Nthenya LN Ha Betty B Puglisi Elisabetta Viani EV

Current opinion in structural biology 20200908

Many viruses, including Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Human Immunodeficiency Virus (HIV), use RNA as their genetic material. How viruses harness RNA structure and RNA-protein interactions to control their replication remains obscure. Recent advances in the characterization of HIV-1 reverse transcriptase, the enzyme that converts its single-stranded RNA genome into a double-stranded DNA copy, reveal how the reverse transcription complex evolves during initiation ...[more]

PMID: 32916568

Similar Datasets

Distinct Conformational States Underlie Pausing during Initiation of HIV-1 Reverse Transcription.

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