Ontology highlight
ABSTRACT:
SUBMITTER: Koma A
PROVIDER: S-EPMC8469660 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Koma Ayaka A Asai Shunichi S Minemura Chikashi C Oshima Sachi S Kinoshita Takashi T Kikkawa Naoko N Koshizuka Keiichi K Moriya Shogo S Kasamatsu Atsushi A Hanazawa Toyoyuki T Uzawa Katsuhiro K Seki Naohiko N
International journal of molecular sciences 20210914 18
We newly generated an RNA-sequencing-based microRNA (miRNA) expression signature of head and neck squamous cell carcinoma (HNSCC). Analysis of the signature revealed that both strands of some miRNAs, including <i>miR-139-5p</i> (the guide strand) and <i>miR-139-3p</i> (the passenger strand) of <i>miR-139</i>, were downregulated in HNSCC tissues. Analysis of The Cancer Genome Atlas confirmed the low expression levels of <i>miR-139</i> in HNSCC. Ectopic expression of these miRNAs attenuated the ch ...[more]