Unknown

Dataset Information

0

MiR-486-3p, miR-139-5p, and miR-21 as Biomarkers for the Detection of Oral Tongue Squamous Cell Carcinoma.

ABSTRACT: Oral tongue squamous cell carcinoma (TSCC) is a complex disease with extensive genetic and epigenetic defects, including microRNA deregulation. The aims of the present study were to test the feasibility of performing the microRNA profiling analysis on archived TSCC specimens and to assess the potential diagnostic utility of the identified microRNA biomarkers for the detection of TSCC. TaqMan array-based microRNA profiling analysis was performed on 10 archived TSCC samples and their matching normal tissues. A panel of 12 differentially expressed microRNAs was identified. Eight of these differentially expressed microRNAs were validated in an independent sample set. A random forest (RF) classification model was built with miR-486-3p, miR-139-5p, and miR-21, and it was able to detect TSCC with a sensitivity of 100% and a specificity of 86.7% (overall error rate = 6.7%). As such, this study demonstrated the utility of the archived clinical specimens for microRNA biomarker discovery. The feasibility of using microRNA biomarkers (miR-486-3p, miR-139-5p, and miR-21) for the detection of TSCC was confirmed.

SUBMITTER: Chen Z 

PROVIDER: S-EPMC5224348 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

miR-486-3p, miR-139-5p, and miR-21 as Biomarkers for the Detection of Oral Tongue Squamous Cell Carcinoma.

Chen Zujian Z   Yu Tianwei T   Cabay Robert J RJ   Jin Yi Y   Mahjabeen Ishrat I   Luan Xianghong X   Huang Lei L   Dai Yang Y   Zhou Xiaofeng X  

Biomarkers in cancer 20170109

Oral tongue squamous cell carcinoma (TSCC) is a complex disease with extensive genetic and epigenetic defects, including microRNA deregulation. The aims of the present study were to test the feasibility of performing the microRNA profiling analysis on archived TSCC specimens and to assess the potential diagnostic utility of the identified microRNA biomarkers for the detection of TSCC. TaqMan array-based microRNA profiling analysis was performed on 10 archived TSCC samples and their matching norm  ...[more]

Similar Datasets

Unknown Circulating miR-21-5p and miR-148a-3p as emerging non-invasive biomarkers in thymic epithelial tumors.
| S-EPMC4847810 | biostudies-other
Unknown Dual tumor-suppressors miR-139-5p and miR-139-3p targeting matrix metalloprotease 11 in bladder cancer.
| S-EPMC5021030 | biostudies-literature
Unknown Impact of Oncogenic Targets by Tumor-Suppressive <i>miR-139-5p</i> and <i>miR-139-3p</i> Regulation in Head and Neck Squamous Cell Carcinoma.
| S-EPMC8469660 | biostudies-literature
Clinical PETACC-8 miR-31-3p and miR-31-5p Ancillary Study
| 2260465 | ecrin-mdr-crc
Unknown Analysis of miR-9-5p, miR-124-3p, miR-21-5p, miR-138-5p, and miR-1-3p in Glioblastoma Cell Lines and Extracellular Vesicles.
| S-EPMC7698225 | biostudies-literature
Unknown Regulation of Oncogenic Targets by the Tumor-Suppressive <i>miR-139</i> Duplex (<i>miR-139-5p</i> and <i>miR-139-3p</i>) in Renal Cell Carcinoma.
| S-EPMC7764717 | biostudies-literature
Unknown Tumor-suppressive function of miR-139-5p in esophageal squamous cell carcinoma.
| S-EPMC3799985 | biostudies-literature
Unknown Plasma Small Extracellular Vesicles Derived miR-21-5p and miR-92a-3p as Potential Biomarkers for Hepatocellular Carcinoma Screening.
| S-EPMC7391066 | biostudies-literature
Unknown Association of miR-21-5p, miR-122-5p, and miR-320a-3p with 90-Day Mortality in Cardiogenic Shock.
| S-EPMC7662780 | biostudies-literature
Transcriptomics Differentially expressed genes after transfection of miRNA in a human cancer cell line (miR-139-5p and miR-139-3p)
2023-10-11 | GSE242241 | GEO