Interferon-Induced HERC5 Inhibits Ebola Virus Particle Production and Is Antagonized by Ebola Glycoprotein.
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ABSTRACT:
SUBMITTER: Paparisto E
PROVIDER: S-EPMC8472148 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
Interferon-Induced HERC5 Inhibits Ebola Virus Particle Production and Is Antagonized by Ebola Glycoprotein.
Paparisto Ermela E Hunt Nina R NR Labach Daniel S DS Coleman Macon D MD Di Gravio Eric J EJ Dodge Mackenzie J MJ Friesen Nicole J NJ Côté Marceline M Müller Andreas A Hoenen Thomas T Barr Stephen D SD
Cells 20210913 9
Survival following Ebola virus (EBOV) infection correlates with the ability to mount an early and robust interferon (IFN) response. The host IFN-induced proteins that contribute to controlling EBOV replication are not fully known. Among the top genes with the strongest early increases in expression after infection in vivo is IFN-induced HERC5. Using a transcription- and replication-competent VLP system, we showed that HERC5 inhibits EBOV virus-like particle (VLP) replication by depleting EBOV mR ...[more]
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