Ontology highlight
ABSTRACT:
SUBMITTER: Cai Y
PROVIDER: S-EPMC7790382 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Cai Yingyun Y Yu Shuiqing S Chi Xiaoli X Radoshitzky Sheli R SR Kuhn Jens H JH Berger Edward A EA
PloS one 20210107 1
Ebola virus (EBOV), a member of the mononegaviral family Filoviridae, causes severe disease associated with high lethality in humans. Despite enormous progress in development of EBOV medical countermeasures, no anti-EBOV treatment has been approved. We designed an immunotoxin in which a single-chain variable region fragment of the EBOV glycoprotein-specific monoclonal antibody 6D8 was fused to the effector domains of Pseudomonas aeruginosa exotoxin A (PE38). This immunotoxin, 6D8-PE38, bound spe ...[more]