Dataset Information

The association between single nucleotide polymorphism in vitamin D receptor and calcium oxalate urolithiasis in dogs.

ABSTRACT:

Background

Polymorphisms of the vitamin D receptor (VDR) are associated with calcium oxalate (CaOx) nephrolithiasis in humans.

Objectives

To investigate the association between VDR polymorphisms and susceptibility to CaOx urolithiasis in dogs.

Animals

Thirty-five dogs with CaOx urolithiasis were compared with 40 stone-free dogs.

Methods

This was a case-control study. Two VDR gene polymorphisms (rs851998024 and rs852900542) were detected by specific TaqMan real-time polymerase chain reaction assay, and their relationship with serum 1,25-dihydroxyvitamin D, serum and urinary electrolyte concentrations was evaluated.

Results

The distribution of the rs852900542 polymorphism was significantly different between the case and the control dogs (x² = 6.369, P = .04). Dogs with a CC or CT genotype had an increased risk of CaOx stones than those with the TT genotype (odds ratio = 3.82, 95% confidence interval 1.04-13.98). The CaOx dogs with the TT genotype had a significantly lower urinary calcium-to-creatinine ratio than the CT+CC genotypes. 1,25-(OH)2D concentrations did not differ between the cases and the controls (308.7 ± 217.4 vs 286.7 ± 185.1 pg/mL, P = .45).

Conclusions and clinical importance

This finding suggests that vitamin D metabolism might play a role in CaOx stone formation in dogs.

SUBMITTER: Chamsuwan S

PROVIDER: S-EPMC8478019 | biostudies-literature |

REPOSITORIES: biostudies-literature

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