Glucosamine protects against neuronal but not vascular damage in experimental diabetic retinopathy.

ABSTRACT:

Objective

Glucosamine, an intermetabolite of the hexosamine biosynthesis pathway (HBP), is a widely used nutritional supplement in osteoarthritis patients, a subset of whom also suffer from diabetes. HBP is activated in diabetic retinopathy (DR). The aim of this study is to investigate the yet unclear effects of glucosamine on DR.

Methods

In this study, we tested the effect of glucosamine on vascular and neuronal pathology in a mouse model of streptozotocin-induced DR in vivo and on cultured endothelial and Müller cells to elucidate the underlying mechanisms of action in vitro.

Results

Glucosamine did not alter the blood glucose or HbA_1c levels in the animals, but induced body weight gain in the non-diabetic animals. Interestingly, the impaired neuronal fun

SUBMITTER: Eshwaran R 

PROVIDER: S-EPMC8479835 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature